Structure

The crystal structure of the PCI domain from Arabidopsi CSN7 (1)

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PCI proteins

subunit	mammals	plants	Drosophila	C. elegans (2)	N.crassa	Aspergillus	S. pombe	S. cerevicea (3)	other yeasts
CSN1	yes	yes	yes	yes	yes	yes	yes	yes	C.a., C.m.
CSN2	yes	yes	yes	yes	yes	yes	yes	yes	C.a., C.m.
CSN3	yes	yes	yes	yes	yes	yes	yes	yes	C.a., C.m.
CSN4	yes	yes	yes	yes	yes	yes	yes	no
CSN7a	yes	yes	yes	maybe	yes	yes	yes	yes	C.a., C.m.
CSN7b	yes	no	no	no	no	no	no	no
CSN8	yes	yes	yes	no	no	no	no	no
RPN7	yes	yes	yes	yes	yes	yes	yes	yes
RPN6	yes	yes	yes	yes	yes	yes	yes	yes
RPN3	yes	yes	yes	yes	yes	yes	yes	yes
RPN5	yes	yes	yes	yes	yes	yes	yes	yes
RPN9	yes	yes	yes	yes	yes	yes	yes	yes
RPN12	yes	yes	yes	yes	yes	yes	yes	yes
eIF3a	yes	yes	yes	maybe	yes		yes	yes
eIF3c	yes	yes	yes	maybe	yes		yes	yes
eIF3e	yes	yes	yes	maybe	yes		yes	maybe
eIF3j	yes	yes	maybe	maybe	yes		yes	yes
eIF3k	yes	yes	yes	maybe	yes		no	no
eIF3l	yes	yes	no	maybe	yes		no	no

Notes

1 : Dessau, M., Halimi, Y., Erez, T., Chomsky-Hecht, O., Chamovitz, D.A., and Hirsch, J.A. (2008). The Arabidopsis COP9 Signalosome Subunit 7 Is a Model _PCI- Domain Protein with Subdomains Involved in COP9 Signalosome Assembly. Plant Cell 20, 2815-2834.

2 : C. elegans contains a protein , CIF1, which is likely a dual-function CSN7/eIF3l; http://mcb.asm.org/cgi/content/full/27/12/4526

3 : the nomenclature for S. cerevicea is different - we've marked here what Kay Hoffman considered the most likely homolog