Biological Sequences Analysis 2012, MTA

Overview:

The course gives an introduction to the field of sequence analysis in bioinformatics.
During the course various approaches for sequence analysis, and corresponding tools will be taught.

Teaching instructor: Ofir Cohen.

Course hours: Thursday, 16:15 - 18:00.

Check out the updated syllabus

Announcements:

06.03.2012 - First lesson Welcome!
17.04.2012 - HW 1. Due date: 1 May 2012. (10% of grade ,obligatory submission)
24.04.2014 - Mid-term. (20% of grade, considered as 'MAGEN')

Course materials:

Class Date Topic Presentation Assignments Useful stuff
Lesson 1 06.03.2012  The genome era -
 revolutionizing science at the turn of the century
01Introduction.GenomeEra.ppt    
Lesson 2 13.03.2011    Computational biology - introduction 02Introduction.ComputationalBiology.ppt    
Lesson 3 20.03.2012    Inside The Genome 03insideTheGenome.ppt    
Lesson 4 27.03.2012    Statistical concepts, SeqAlignment(part 1) and BLAST(part 1) 04SeqAlignment.I.BLAST.andPvalue.ppt    
Lesson 5 03.04.2012    SeqAlignment(part 2) and BLAST(part 2) 05SeqAlignment.II.BLAST.II.pptx    
Lesson 6 17.04.2012    Databases and Blast (lab) 06Databases_and_Blast.pptx HW1 due on 01.05  
Lesson 24.04.2011     Mid term MidTerm2012.withAns.doc    
Lesson 7 01.05.2011     MSA and it's applications 07MSA.and.applications.ppt    
Lesson 8 08.05.2012     Evolution and Phylogeny 08phylogeny.Evolution.ppt    
Lesson 9 15.05.2012     Homology, Tree Construction (part I) 09Homology.TreeConstruction_I.ppt    





Database or application name Contents URL
NCBI Sequences, structures, diseases, publications, and more http://www.ncbi.nlm.nih.gov
EMBL-EBI Data resources and tools http://www.ebi.ac.uk
PubMed Biomedical publications http://www.ncbi.nlm.nih.gov/pubmed
Google scholar Publications http://scholar.google.co.il
Swiss-Prot Protein knowledgebase http://www.expasy.ch/sprot
PDB Database of biological macromolecules http://www.rcsb.org/pdb/home/home.do
GO Gene ontology database http://www.geneontology.org
NCBI BLAST All BLAST tools http://blast.ncbi.nlm.nih.gov/Blast.cgi
EMBL-EBI ClustalW An interface to a multiple sequence alignment program http://www.ebi.ac.uk/Tools/clustalw2
PhyML An interface to a phylogeny reconstruction program http://atgc.lirmm.fr/phyml
Prosite Database of protein domains, families, and functional sites http://www.expasy.org/prosite
UCSC Genome browser http://genome.ucsc.edu
Ensembl Genome browser http://www.ensembl.org
ConSeq A server for the identification of functionally and structurally important residues in protein sequences http://conseq.tau.ac.il
ConSurf A server for the identification of functionally and structurally important residues in protein structures http://consurf.tau.ac.il
Selecton A server for the identification of site-specific positive selection & purifying selection http://selecton.tau.ac.il